FXI inhibition reduces platelet and fibrin deposition on collagen-coated vascular grafts. Effects of FXI inhibition on (A) platelet and (B) fibrin deposition on collagen-coated (4-mm id) vascular grafts. The grafts were placed in vehicle-treated (n = 8) or aXIMab-treated (n = 6) animals (≥ 99% FXI inhibition). Blood was allowed to flow through the devices at 100 mL/min, producing an initial average wall shear rate of 265 s⁻¹. Significance levels (**P < .01, ***P = .001) were calculated by the 2-tailed Student t test. Values are means plus or minus SEM.