S36578 inhibited HIV-1 replication in MDMs. (A) S36578 integrin antagonist inhibited HIV-1 replication with both R5 and X4 tropic HIV-1 strains. Percentage of replication measured as p24 production 7 days after infection for BaL and 92UG024 is shown. Data are the mean plus or minus SD of at least 3 independent experiments. (B) S36578 anti-HIV activity in VSV-pseudotyped HIV. Percentage of luciferase expression 3 days after infection with a VSV-G–pseudotyped HIV is represented. Data are the mean plus or minus SD of at least 3 independent experiments. ND indicates no drug. *P < .05; **P < .005; ***P < .001.