Cumulative incidence of treatment success and treatment failure. The lower black curves and left scale represent the cumulative incidence of discontinued systemic treatment for chronic GVHD without secondary therapy for chronic GVHD, development of bronchiolitis obliterans, recurrent malignancy during primary treatment for chronic GVHD, or death during primary treatment for chronic GVHD; upper gray curves and right scale, cumulative incidence of treatment failure, including secondary therapy for chronic GVHD, development of bronchiolitis obliterans, recurrent malignancy during primary treatment for chronic GVHD, or death during primary treatment for chronic GVHD. The gap between the lower and upper curves indicates the proportion of patients continuing primary treatment for chronic GVHD without recurrent malignancy or development of bronchiolitis obliterans. Vertical line at 2 years represents the prespecified interval time designated for assessment of the primary endpoint; —, MMF group; and ----, control group.