CT and histopathologic evaluation of hemophilia B dogs after liver-directed AAV gene therapy. After contrast sagittal CT sections of hemophilia B dog Brad (A) and hemophilia B dog Semillon (B) livers. H&E sections (×200) of liver biopsy obtained 6 years after vector administration in Brad (C) and Semillon (D). The CT evaluation, liver biopsy, and histologic processing were as described. GB indicates gall bladder.