Inhibition of DTT-induced fibrinogen binding by tirofiban and eptifibatide. Inhibition of DTT-induced fibrinogen binding to CHO cells expressing WT HαIIb with Hβ3 (HαIIb), WT rat αIIb with Rβ3, and the designated human/rat αIIb chimeras with Hβ3 by 10 nM tirofiban or 60 nM eptifibatide. Data shown are the mean plus or minus 1 SE of 3 or more separate experiments.