Figure 4
Figure 4. IFNs are key components of the NK cell–mediated CD8+ T-cell responses. (A-C) CD8+ T-cell responses as measured by IFN-γ production upon restimulation with OVA257-264 peptide ex vivo (day 8) and OVA-specific total IgG (measured day 14) in wild-type, IFN-αR, IFN-γR, and IFN-α/IFN-γR double-deficient mice. Values represent the mean ± SEM of pooled data from 3 to 4 independent experiments (*P ≤ .05).

IFNs are key components of the NK cell–mediated CD8+ T-cell responses. (A-C) CD8+ T-cell responses as measured by IFN-γ production upon restimulation with OVA257-264 peptide ex vivo (day 8) and OVA-specific total IgG (measured day 14) in wild-type, IFN-αR, IFN-γR, and IFN-α/IFN-γR double-deficient mice. Values represent the mean ± SEM of pooled data from 3 to 4 independent experiments (*P ≤ .05).

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