Pre-miR 29b is fragmented by dicer. The active miR 29b binds DNMT3A, 3B, and Sp1 mRNA either blocking translation or targeting them for degradation. Loss of Sp1 protein in turn down-regulates DNMT1 expression.
Pre-miR 29b is fragmented by dicer. The active miR 29b binds DNMT3A, 3B, and Sp1 mRNA either blocking translation or targeting them for degradation. Loss of Sp1 protein in turn down-regulates DNMT1 expression.
