STAT3 mRNA is highly expressed in ABC-DLBCL compared with GCB-DLBCL. (A) Northern blot analysis of BCL6 and STAT3 in DLBCL cell lines. The 28S indicates 28S ribosomal RNA used as loading control. Vertical lines have been inserted to indicate a repositioned gel lane. (B) BCL6, STAT3, and cyclin D2 expression patterns based on previously published DLBCL gene expression data.³  The signal values for BCL6 (probe 24429), STAT3 (probe 31469), and cyclin D2 (probe 16858) were retrieved for 72 ABC-DLBCL and 114 GCB-DLBCL samples. The data had been previously log₂ transformed and median centered for each gene across the entire sample set. The P values are based on Wilcoxon-Mann-Whitney nonparametric test performed to compare the values between the 2 subgroups. Bars indicate the group means for each column. Mean, group mean of the log₂-transformed values; Fold change, linear fold difference between the group means.