Blockade of TF, anticoagulation, or monocyte depletion prevents fetal death and IUGR in CBA/J × DBA/2 mice. CBA/J × BALB/c mice, CBA/J × DBA/2 mice, and CBA/J × DBA/2 mice that received different treatments were killed on day 15 of pregnancy, uteri were dissected, and fetal resorption rates (A) and fetal weight were recorded (B). (C) Litter size at birth. (D) Immunohistochemical analysis for TF in a section of decidua from CBA/J × DBA/2 mice depleted of monocytes with Cl₂MDP. Minimal amounts of TF and intact embryo (e) were observed in deciduas (d) of CBA/J × DBA/2 mice depleted of monocytes. Original magnification ×40. (E) FACS analysis of TF expression on whole blood monocytes from BALB/c- and DBA/2-mated CBA/J mice. The number of TF-positive monocytes increased in CBA/J × DBA/2 mice in comparison with CBA/J × BALB/c mice (P < .001). n = 5-8 mice/each experimental group. Four to 5 placentas per mouse were studied. Data are mean values plus or minus SD.