The effect of cellular infusions on survival and donor engraftment of Col7a1^−/− (RDEB) mice. (A) Blue line indicates nontreated RDEB mice (n = 18); red line: RDEB mice given nonenriched BM (n = 24); and green line: RDEB mice treated with CD150⁺48⁻ BM (n = 20; P = .005 and P = .005 versus nontreated or nonenriched BM-treated RDEB mice, respectively). (B) Histograms of peripheral blood of the animal with the highest donor engraftment (9.58%) 10 weeks after CD150⁺48⁻ BM infusion (left panel) and unmanipulated control (right panel). (C) BM cells explanted from the surviving recipients express col7 protein. Representative example is shown. (Top panel) GFP-expressing donor cells (green); (middle panel) col7-expressing donor cells (red); (bottom panel) merged image; arrows point to donor cells coexpressing GFP and col7 protein.