Vaccination with DCs cocultured with irradiated, mAb-coated tumor cells provides protection superior to vaccination with Id-KLH protein. Pooled survival data of mice receiving 2 biweekly injections of either DCs loaded with irradiated, mAb-coated tumor cells (n = 82) or Id-KLH protein alone or with either IL-12 or GM-CSF adjuvant (n = 82) in 7 separate experiments are shown. Two weeks after vaccinations, mice were injected with 38C13 subcutaneously, followed for tumor growth, and killed when their tumors reached 1.4 cm in diameter.