Pol II, E2F1, and myc are recruited to the miR106b promoter in response to deacetylase inhibition. (A) Structure and regulation of the Mcm7-miR106b gene. (B) Phosphorylation of serine 10 and acetylation of lysine 9/14 on histone H3 in response to LBH589. (C) Increase in H3AcK9/14 at Amplicon A within the promoter of miR106b from 2 individual CLL samples. (D) Increased recruitment of E2F1 and myc to the promoter of miR106b in the same CLL samples. (E) Coordinate expression of Mcm7 and miR106b by qRT-PCR in the aforementioned CLL samples.