Serial detection of CTAg-specific CD4⁺ T-cell responses in patients with MGUS and myeloma. (A) The CTAg-specific CD4⁺ T-cell response was determined at several time points in a patient with myeloma. (B) Similar analysis was performed in 3 patients with MGUS. The x-axis indicates the number of days from diagnosis; ----, paraprotein level; and —, MAGE-A3–specific CD4⁺ T-cell response from the point of analysis. Treatment regimens are shown. VAD indicates vincristine, doxorubicin, and dexamethasone; and PBSCT, peripheral blood stem cell transplantation.