Classification of SALL4-bound genes in NB4 leukemia cells. SALL4 target genes were classified based on annotations important to cell growth and cell death extracted from Ingenuity Pathway Analysis. It should be noted that specific genes may be represented in more than one classification group. (A) Classification of SALL4 target genes is based on signaling pathways associated apoptosis and cell growth properties according to Ingenuity Pathway Analysis knowledge base. P values for this analysis are not presented due to the low number of genes within each pathway. The first and second percentages represent the number of genes bound within each pathway relevant to the total SALL4 binding and the total number of genes within each pathway relevant to the genes on the array, respectively. (B) Classification of molecular functions associated with SALL4 target genes. The P values presented for each category are calculated using Fisher exact test against the genes represented on the promoter tiling array. The first and second percentages are the total number of genes bound by SALL4 in each function relevant to the number of genes bound by SALL4 and the number of genes on the array that are classified in each function compared with the total number of genes represented on the array, respectively. Unannotated genes were removed from this analysis, and the analysis was done using the top tier of SALL4-bound genes. The genes bound by SALL4 and the genes within each classification are presented in Table S2.