Safety of continuous expression of cFVIIa. Platelet counts (PLT) (A), levels of TAT (B), D-dimer (C), and fibrinogen (D) are shown as a function of time, after AAV8-cFVIIa administration (arrow). Day 0 is indicated by a dotted line. A shaded box represents the range of values for normal (N), HA, or HB dogs (except in panel D where it is indicated for HA, N, and HB separately).