Cell lines versus normal centroblast miRNA expression comparison. (A) Hierarchical clustering of cell lines and their normal counterparts (centroblasts) using the 82 miRNAs with differential expression between these 2 groups based on SAM analysis. miRNAs comprising the 39 miRNA cell-of-origin classifiers are framed in red; miRNAs with differential expression between DLBCL subtypes are framed in green. (B) Classifier of 5 miRNAs obtained from the PAM algorithm to differentiate DLBCL cell lines from their normal counterparts. Mean centered log ratios for each miRNA are represented. Missing values are in gray. CB indicates centroblast; GCB, germinal center–like DLBCL; and ABC, activated B cell–like DLBCL.