Overall survival in years for 3 representative genes showing patients treated with CHOP versus R-CHOP according to gene expression levels.HLA-DRB is cut above and below 25%; BCL6 and MYC are cut at median. (A) CHOP-treated cases, all IPI scores: (Ai) HLA-DRB; (Aii) BCL6; (Aiii) MYC (N = 93). (B) R-CHOP cases, all IPI scores, HLA-DR, BCL6, and MYC (N = 116).