Overall clinical outcomes on Total Therapy 2. (A) Overall and event-free survival. At 8 years, 50% of patients are alive and 33% have remained event-free. (B) Cumulative complete and near-complete response. At 3 years, 72% have achieved near-complete response (n-CR), including 50% who achieved complete response (CR). (C) Duration of CR or n-CR. Of those achieving response, 8-year estimates of CR and n-CR are 49% and 42%, respectively.