Negative correlation between percentage of HHV-8–specific CCR7⁻CD27⁺CD45RA⁻/CD8⁺ IFN-γ⁺ effector cells and individual HHV-8 viral loads. The percentage of HHV-8–specific CCR7⁻CD27⁺CD45RA⁻ early and intermediate effector memory cells in CD8⁺ IFN-γ⁺ cells as assessed by intracellular IFN-γ staining after HHV-8 epitope stimulation was negatively correlated with individual HHV-8 viral loads in PBMC for 5 MCD and 7 AC patients (Spearman nonparametric test). Each symbol represents a patient. Rhombus shapes represent patients with active MCD; circles, MCD patients in remission; squares, AC.