Impact of age on total genomic alteration (TGA) in CD34⁺ cells of lower-risk MDS patients. (A) Scatter-plot of age at diagnosis versus log (TGA). An increase in TGA is observed with increasing age in MDS patients (n = 44). (B) Distribution of TGA in CD34⁺ cells from normal controls (n = 15), MDS patients with an abnormal karyotype (n = 15), and MDS patients with a normal karyotype (n = 25). The dashed line represents a TGA of 3 Mb.