American Society of Hematology

Figure 5

$Figure 5. Diagrammatic expression profiles of NKG2D and 4-1BB in conjunction with cytotoxic effector status. (1) Naive cells: naive CD8+ T cells express NKG2D, but no 4-1BB on the cell surface. They have NKG2D susceptible to down-modulation in the presence of TGF-β1 and IL-4 becoming cells lacking both NKG2D and 4-1BB. (2) NKG2D-costimulated cells: these cells lack NKG2D and express induced 4-1BB, representing activated yet immature cells with the capacity for cytotoxic activity. (3) Cytotoxic cells: 4-1BB costimulation of NKG2D-costimulated cells results in another cell type expressing both NKG2D and 4-1BB on the cell surface. These cells are highly cytotoxic and are refractory to TGF-β1 inhibition. (4) Incapacitated cells: these cells lack both NKG2D and 4-1BB and manifest no cytotoxic activity. These cells may be derived from naive or NKG2D costimulated cells by losing NKG2D or 4-1BB, respectively, in the presence of soluble MIC, IL-4, and TGF-β1.$

Diagrammatic expression profiles of NKG2D and 4-1BB in conjunction with cytotoxic effector status. (1) Naive cells: naive CD8⁺ T cells express NKG2D, but no 4-1BB on the cell surface. They have NKG2D susceptible to down-modulation in the presence of TGF-β1 and IL-4 becoming cells lacking both NKG2D and 4-1BB. (2) NKG2D-costimulated cells: these cells lack NKG2D and express induced 4-1BB, representing activated yet immature cells with the capacity for cytotoxic activity. (3) Cytotoxic cells: 4-1BB costimulation of NKG2D-costimulated cells results in another cell type expressing both NKG2D and 4-1BB on the cell surface. These cells are highly cytotoxic and are refractory to TGF-β1 inhibition. (4) Incapacitated cells: these cells lack both NKG2D and 4-1BB and manifest no cytotoxic activity. These cells may be derived from naive or NKG2D costimulated cells by losing NKG2D or 4-1BB, respectively, in the presence of soluble MIC, IL-4, and TGF-β1.

This Feature Is Available To Subscribers Only