MDM2 and TP53 interaction in t-AML. Data regarding interactions between MDM2 309 and TP53 72 alleles were consistent with double-homozygous-state TT and Arg/Arg, or any genotype with at least one MDM2 SNP 309G and one TP53 codon 72 Pro resulting in increased risk of t-AML. Any TP53 Pro–containing genotype with MDM2TT was protective.

MDM2 and TP53 interaction in t-AML. Data regarding interactions between MDM2 309 and TP53 72 alleles were consistent with double-homozygous-state TT and Arg/Arg, or any genotype with at least one MDM2 SNP 309G and one TP53 codon 72 Pro resulting in increased risk of t-AML. Any TP53 Pro–containing genotype with MDM2TT was protective.

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