Representative examples of the enrichment of CNVs and segmental duplications in MCL breakpoints. Association of MCL chromosomal breakpoints in CNV/SDs loci based on computational simulations that compared the expected number of breakpoints containing CNV/SDs with the observed number in MCL cell lines and primary tumors. A significant enrichment of breakpoints in CNV loci was found for UPDs/UPTs (A) and chromosomal losses (B). Similarly, a significant enrichment of breakpoints in SD loci was found for losses (C), whereas breakpoints of chromosomal gains have no association with SDs (D).