sHSP70 induces T-cell proliferation. CD3⁺ T cells were labeled with CSFE and stimulated under different conditions for 1 week. Cell proliferation within the CD4⁺ T-cell populations was evaluated by CFSE dilution. (A) One representative experiment of CD4⁺ T-cell proliferation under different stimulation conditions and using the control protein sCMVpp65 or sSema7A in the absence or presence of IL-2. (B) One representative experiment of CD4⁺ T-cell proliferation under different stimulation conditions. (C) Results of 8 independent experiments are mean plus or minus SD. **P < .01.