Kaplan-Meier survival curves of disease-free survival and overall survival stratified by different angiogenetic changes at diagnosis. The low versus high Peak group showed significant differences in overall survival (P = .002; A) and disease-free survival (P = .007; D). The Amp also showed significant implication in overall survival (P = .014; B) and disease-free survival (P = .003; E). However, the permeability parameter K trans showed no influence on overall and disease-free survival (C,F).