Patterns of response in 72 patients on BiRD per treatment cycle. (A) Tumor mass reduction and event-free survival (inset) and (B) cumulative response; mean time on treatment, 368 days (range, 29-944 days); mean duration of response, 333 days (range, 15-920 days). Mean time to first response, 53.9 days (range, 21-816 days); mean time to maximum response, 209 days (range, 27-850 days). A total of 74% of patients achieved a greater than 90% reduction in M-protein level (mean time to very good partial response, 158 days; range, 28-786 days). Fifty-one (71%) of 72 patients had a more than 50% decrease in M-protein level at the end of the first cycle.