Effect of VEGF-Trap on neonatal mouse thymocytes. (A) Graph showing total thymocyte numbers isolated from mice given VEGF-Trap or Fc control on day 1, and analyzed 7 days later. *P < .001. (B) Effect of VEGF inhibition on T-cell subset numbers. The CD4⁻CD8⁻ and CD4⁺CD8⁻ cells are shown as cell number × 10⁶ (#), whereas the CD4⁺CD8⁺ cell subset is cell number × 10⁷ (##). *P = .04; **P = .004; ***P < .001. n = 4 pooled VEGF-Trap litters (■) and n = 5 individual Fc control mice (). Error bars represent standard deviation.