Expansion of lymphoid cells in JAK3-AV animals. (A) Comparison of total number of white blood cells (top left panel), spleen weights (top right panel), liver weights (bottom left panel), and total cells after RBC lysis in different organs (bottom right panel) in recipients of JAK3-WT–transduced bone marrow (■) versus JAK3-AV–transduced bone marrow (□). (B) Flow cytometric analysis of the different lymphoid compartments. All analyses are gated on GFP+ cells; plots are representative of at least 5 independent experiments. Percentages are indicated. (C) Subpopulation analysis of lymphocytes migrating to the different lymphoid organs in JAK3-AV or JAK3-WT recipients. BM indicates bone marrow; Spl, spleen; and Thy, thymus. Bar graphs represent the average and standard deviation obtained from at least 5 animals.