Flavopiridol exposure and response. Relationship between response category and AUC_0-∞ or mean AUC_0-∞ (ie, average of AUC_0-∞ from initial and escalated doses) represented as a (A) dot plot or (B) box plot. ANOVA P values are displayed for comparison of PD/SD versus PR (.011) and PD versus SD/PR (.154). PD indicates progressive disease; SD, stable disease; and PR, partial response.