PK profiles. Semilogarithmic flavopiridol plasma concentration versus time plots for doses 30 + 30 (A), 40 + 40 (B), and 30 + 50 mg/m² (C), and mean plus SD values for each dose level (D) (filled circles represent 30 + 30 mg/m²; squares, 40 + 40 mg/m²; and open circles, 30 + 50 mg/m²). The curve for the 40 + 40 mg/m² dose level does not include SD because data from only 2 patients were available for mean calculation. The inset in panel D displays a linear y-axis to better illustrate the increased AUC achieved with the escalated dose (30 + 50 mg/m²).