Aggregate of positive (top) and negative (bottom) time courses formed by plotting chronologic HIC and cardiac R2* measurements for 38 subjects. Cardiac R2* (equal to 1000/T2*) is on the vertical axis in log scale; HIC (calculated using liver R2 and R2*) is on the horizontal axis. First and last MRI measurements are denoted by a filled circle and an “x,” respectively. In the plot of positive time courses, the time courses having AUCs more than 37.2 (the largest negative AUC) are indicated by dark lines and the smaller AUCs, by light gray lines. The time course indicated by a thick, black line is representative of the counterclockwise movement of these time courses as a whole. The inset in the top left corner shows the numbered “limbs.” In the plot of negative time courses, all time courses are shown in light gray except one. The time course indicated by a thick, black line is a representative of the clockwise movement of these time courses as a whole.