Protein expression against SGs. Proteins were clustered into 10 constellations shown by the 10 colored boxes along the left axis and the yellow lines surrounding each constellation. Based on the score for each constellation for each patient, an overall score was generated, and this divided patients into 7 protein SGs (bottom of heatmap). The average score for each protein constellation within each SG is shown. An additional heatmap showing the expression of each protein in each individual patient is available online as Figure S2. The fold change between −2 SDs and 2 SDs for each individual protein, corresponding to the −2 (green) to +2 (red) color gradient bar shown in the upper left corner, is listed to the right of the protein name.