Cytotoxicity of ara-C in CEU and YRI populations. (A) The mean percentage survival in the CEU compared with the YRI cell lines was 73.3 versus 70.5 at 1 μM (P = .24), 53.3 versus 47.3 at 5 μM (P = .002), 46.8 versus 39.9 at 10 μM (P = 1 × 10⁻⁴), 40.3 versus 32.8 at 40 μM (P < 1 × 10⁻⁴), and 37.3 versus 30.4 (P < 1 × 10⁻⁴) at 80 μM ara-C. (B) The distribution of log₂ AUC in CEU and YRI cell lines (P < 1 × 10⁻⁴).