Figure 7
Figure 7. A schematic model of PIAS3 in osteoclastogenesis. In osteoclast precursors, PIAS3 inhibits the transcriptional activity of MITF, resulting in attenuation of the expression of c-Fos and NFATc1. In osteoblasts, PIAS3 inhibits the IL-6 cytokine family-gp130-STAT3 signaling by suppressing the DNA binding activity of STAT3, resulting in attenuation of the RANKL expression and inhibition of osteoclastogenesis.

A schematic model of PIAS3 in osteoclastogenesis. In osteoclast precursors, PIAS3 inhibits the transcriptional activity of MITF, resulting in attenuation of the expression of c-Fos and NFATc1. In osteoblasts, PIAS3 inhibits the IL-6 cytokine family-gp130-STAT3 signaling by suppressing the DNA binding activity of STAT3, resulting in attenuation of the RANKL expression and inhibition of osteoclastogenesis.

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