Phenotypic characterization of SRS19-6–injected mice. (A) Morphology of bone marrow cells and peripheral blood cells derived from a nonleukemic control mouse, a mouse with AML, and a mouse with T-ALL. Cells were stained with May-Grünwald-Giemsa. (B) Splenic sections were stained for myeloperoxidase (MPO) demonstrating the accumulation of immature myeloid cells in AML mice. (C) Disruption of the splenic architechture in the AML mouse. Sections were stained with hematoxylin-eosin (HE). (D) Massive infiltration of leukemic cells in the liver of an AML mouse. Sections were stained as in panel C. Arrows mark the boundary between infiltrating myeloid cells (left) and the normal liver tissue (right). Microscopy was performed using an Olympus BX40 microscope (Olympus, Cophenhagen, Denmark) mounted with an Olympus DP10 digital camera using the following lenses: 10× Plan0.25, 40× UplanFL0.75, or 100× Plan1.25 oil. Images were processed in Adobe Photoshop CS3 v.10.0.1 and Adobe Illustrator CS3 v13.0.2 (Adobe Systems, San Diego, CA).