In vivo stimulation of F36V-Mpl signaling in human multilymphoid progenitors. (A) In vivo longitudinal imaging of luciferase expression in 2 NOD/SCID/β₂-microglobulin^−/− mice that received transplants with CD34⁺CD38⁻Lin⁻CD7⁺ cells transduced with F36V-MPL and treated with or without CID from day 1; D indicates dorsal view; V, ventral views. (B) Quantification of signal for all animals, n = 6 mice per arm, 2 independent experiments; mean and SD; P = .001 for difference between F36V-MPL with CID and all the other groups). (C) Lineage analysis of human cells in bone marrow of representative CID-treated mouse.