The decreasing incidence of transfusion-associated hepatitis in blood recipients monitored prospectively. Incidence, traced from 1969 to 1998, demonstrates a decrease in risk from 33% to nearly zero. Arrows indicate main interventions in donor screening and selection that effected this change. Reprinted with permission of Nature Publishing Group from Alter HJ and Houghton M, Hepatitis C virus and eliminating post-transfusion hepatitis (Nat Med. 2000;6:1082-1086).