Distribution of rHCII variants after arterial injury. HCII^−/− mice were injected with rHCII^WT (A), rHCII^K173Q (B), rHCII^R189H (C), or saline (D) and then subjected to photochemical injury as described in the legend to Figure 2. Frozen sections of arteries harvested 30 minutes after the onset of injury were stained with a polyclonal goat anti–HCII IgG. Arrow indicates internal elastic lamina; arrowhead, external elastic lamina.