Effect of citrullination on the receptor binding properties of CXCL10 and CXCL11 on CXCR3 and CXCR7 transfectants and on PHA-activated T cells. (A) The receptor binding properties of CXCL10 (♦) and CXCL10-Cit₅ (□) on CHO-CXCR3 cells were determined by competition for ¹²⁵I-labeled CXCL10. (B-D) The receptor binding properties of CXCL11 (♦) and CXCL11-Cit₆ (□) on CHO-CXCR3 (B) or CHO-CXCR7 (C) cells and on PHA-activated T cells (D) were determined by competition for ¹²⁵I-labeled CXCL11. Results represent the mean (± SEM) percentage bound labeled chemokine compared with the maximal amount of bound labeled chemokine when no cold ligand was added (3-6 independent experiments).