Figure 6
Figure 6. PHA-739358 reduces phosphorylation of CrkL in BaF3-p210 cells and their IM-resistant mutants. Murine BaF3 and BaF3-p210 cells comprising the M351T, E255K, and T315I mutation were exposed to 5 μM PHA-739358 or 5 μM IM for 24 hours. Intracellular flow cytometry was used to measure CrkL phosphorylation status. See “PHA-739358 reduces phosphorylation of CrkL in BaF3-p210 wt cells and IM-resistant mutants” for details.

PHA-739358 reduces phosphorylation of CrkL in BaF3-p210 cells and their IM-resistant mutants. Murine BaF3 and BaF3-p210 cells comprising the M351T, E255K, and T315I mutation were exposed to 5 μM PHA-739358 or 5 μM IM for 24 hours. Intracellular flow cytometry was used to measure CrkL phosphorylation status. See “PHA-739358 reduces phosphorylation of CrkL in BaF3-p210 wt cells and IM-resistant mutants” for details.

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