Figure 2
Immunohistochemistry showing localization of infused, recombinant bovine MAGP1 at the site of vascular injury. (A) Photomicrographs on the left are cross sections of carotid arteries from MAGP1+/+ and MAGP1−/− mice infused with 50 μg/kg recombinant bovine MAGP1 5 minutes prior to laser-induced injury. Vessels were harvested after complete cessation of blood flow and frozen sections immunostained using a bovine MAGP1-specific antibody. Staining is evident in the thrombus of both genotypes but is particularly prominent in the internal elastic lamina in the MAGP1−/− mouse (↗, and at higher power in panel B). Panels on the right show staining with antibovine MAGP1 of injured vessels from animals not injected with bovine MAGP1.

Immunohistochemistry showing localization of infused, recombinant bovine MAGP1 at the site of vascular injury. (A) Photomicrographs on the left are cross sections of carotid arteries from MAGP1+/+ and MAGP1−/− mice infused with 50 μg/kg recombinant bovine MAGP1 5 minutes prior to laser-induced injury. Vessels were harvested after complete cessation of blood flow and frozen sections immunostained using a bovine MAGP1-specific antibody. Staining is evident in the thrombus of both genotypes but is particularly prominent in the internal elastic lamina in the MAGP1−/− mouse (↗, and at higher power in panel B). Panels on the right show staining with antibovine MAGP1 of injured vessels from animals not injected with bovine MAGP1.

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