Wnt3a increases osteoblastogenesis and reduces osteoclastogenesis in myelomatous bones. (A) Decalcified histologic bone sections of bones engrafted with H929/W3a or H929/EV cells stained for TRAP (red) and osteocalcin (brown). OB indicates osteoblast; OC, osteoclast. (B) Numbers of osteocalcin-expressing osteoblasts and TRAP-expressing multinucleated osteoclasts in implanted bones engrafted with H929/EV and H929/W3a cells. Error bars represent SEM.