Figure 1
![t(10;11)(q23;p15) results in a NUP98/HHEX fusion gene. (A) The G-banded karyotype is 45, X,−Y, t(10;11)(q23;p15)[15]/46, XY[5]. The arrows indicate the reciprocal chromosome translocations. (B) RACE-PCR and genomic characterization: NUP98 and HHEX are fused in-frame, joining nucleotide 1718 (exon 13) of NUP98 to nucleotide 426 (exon 2) of HHEX. Genomic breakpoint occurs inside the intron 13 in NUP98 gene and inside the exon 2 in HHEX gene joining intron 13 of NUP98 to exon 2 of HHEX (nucleotide 418). (C) Double-color double-fusion FISH assay. RP5-1173K1 (red) and RP11-469M1 (green) give a red signal on normal 11, a green signal on normal 10, and a red/green signal on both der(11) and der(10) (arrows).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/111/12/10.1182_blood-2007-09-108175/6/zh80120820370001.jpeg?Expires=1719164425&Signature=oBGBfY0VWDluA6g2EyDdcsU5coQcqJK8Hzboxboxpi2pg9K1VoB2bW6n7JUXRBjy1PagakuwgZ5UKj9AYSSIBzEEWnNs5Vz~r8PBOvzS5W8r7LtcTDShtC3MDuq3vTnuGuMG1uZI2wiX7ZSBI6lpuWwXI2KR7n8HjoRAaAvoSJNK~TwW16jQ1-0vwfZC2Hoj-aBQSZsaZs1w-ZGgdA1ia5xzQ7Tg3KNLPNMiJ7TePcgeiBv0~U1TOxU2oc~fX-jHZimgGkiWzr71~Z2IlaEph015ivcd~r47U-VgCTCEj8wqZEEYYcc62UF7i9PxravrvEewS1pugi58LZDmiWV0HA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
t(10;11)(q23;p15) results in a NUP98/HHEX fusion gene. (A) The G-banded karyotype is 45, X,−Y, t(10;11)(q23;p15)[15]/46, XY[5]. The arrows indicate the reciprocal chromosome translocations. (B) RACE-PCR and genomic characterization: NUP98 and HHEX are fused in-frame, joining nucleotide 1718 (exon 13) of NUP98 to nucleotide 426 (exon 2) of HHEX. Genomic breakpoint occurs inside the intron 13 in NUP98 gene and inside the exon 2 in HHEX gene joining intron 13 of NUP98 to exon 2 of HHEX (nucleotide 418). (C) Double-color double-fusion FISH assay. RP5-1173K1 (red) and RP11-469M1 (green) give a red signal on normal 11, a green signal on normal 10, and a red/green signal on both der(11) and der(10) (arrows).
