Primary erythroid cells from MPD samples are selectively inhibited by lestaurtinib. (A) Proliferation at 100 nM: comparison of means between MPD samples (34.6% ± 20.1%) and NBM controls (71.8% ± 8.9%) is significant (P = .03). (B) Proliferation at 100 nM: comparison of means between MPD samples stratified by presence (V617F⁺, n = 11, mean 28.1% ± 4.8%) or absence (V617F-, n = 7 mean 44.8% ± 8.7%) of JAK2 versus NBM controls (P = .006 by ANOVA). The difference of means between V617F⁺and V617⁻ samples did not reach statistical significance (P = .08 Student t-test). Means, standard error of the mean (shorter horizontal lines), and standard deviation (longer horizontal lines) are depicted for each group.