FLT3 signature prognostically stratifies both FLT3-ITD⁺ and FLT3-ITD⁻ subgroups. Kaplan-Meier overall survival analysis of NK-AML independent test set for PAM-predicted FLT3-ITD mutation in (A) FLT3-ITD⁺ subgroup and (B) FLT3-ITD⁻ subgroup. P values (log rank test) are indicated.