Gross phenotypes of mice after conditional inactivation of PHD2. (A) Body weights of 10-week-old female mice with indicated genotypes after treatment with tamoxifen at E17.5 and at 3 weeks of age. (B) Appearance of ears (top row) and skin (bottom row). Note vascular dilation and erythema in PHD2 flox/flox;Cre-ER mice (right column). (C) Kaplan-Meier survival curves for mice with indicated genotypes. Error bars indicate 1 SD.