DDR1 and NTRK1 somatic mutations map onto activation loop of a prototypical kinase domain. The kinase model was based on the alignment of the DDR1 and NTRK1 sequences onto the structure of the Hck kinase in complex with Src kinase inhibitor (PDB ID 1qcf).²⁶  The N-terminal domain (N-lobe) is in blue, the C-terminal domain (C-lobe) is in magenta, and the activation segment is in yellow. The catalytic Tyr is in ball-and-stick representation, whereas the mutations are represented by red spheres.