Restoration of TβRII by 5-aza-2-deoxycytidine and MS-275 sensitizes PEL cells to apoptotic and cytostatic effects of TGF-β signaling. (A) Analysis of the TGF-β signaling cascade and downstream gene targets, p21 and cyclin A, on indicated treatments. (B) Flow cytometric analysis of apoptosis (top panel) and growth curve (bottom panel) of BC1 and BC3 cells in response to indicated treatments. Line colors correspond to treatment conditions described in the top panel.