Kaplan-Meier curves showing time to RS transformation according to genotype. Cumulative incidence of RS transformation at 5 years performed on the CLL cohort (n = 245), divided on the basis of CD38 genotype. Univariate log-rank analysis identifies G allele as a risk factor for RS transformation (A). The result remains significant even when all G allele carriers are grouped (GG/GC) and compared with CC homozygotes (B). (C) Table showing the 5-year risk of RS transformation according to CD38 genotype.