Figure 2
Figure 2. Amino acid sequences of the CDR3 of the nearly identical Ig heavy and light chains. (A) Amino acid sequences of the CDR3 of the nearly identical Ig heavy and light chains expressed by the 19 unrelated CLL patients of subgroup CLL69B. Alignments of the amino acid sequences of the 51p1 encoded heavy chains and IGKV1-39 light chains are shown compared with CLL69B2. Dots indicate homology and dashes indicate no sequence at that position. Listed on the left is the designation for each CLL sample. The germline sequences of the IGHD2-2, IGHJ6, IGKV1-39 and IGKJ4 genes are shown for reference. Underlined letters (X) designate amino acid differences between the germline IGKJ genes relative to IGKJ4. (B) Amino acid sequences of the CDR3 of the nearly identical Ig heavy and light chains expressed by the 5 unrelated CLL patients of subgroup CLL69D. Alignments of the amino acid sequences of the 51p1 encoded heavy chains and IGKV3-11 light chains are shown compared with CLL69D1. Dots indicate homology and dashes indicate no sequence at that position. Listed on the left is the designation for each CLL sample. The germline sequences of the IGHD2-2, IGHJ6, IGKV3-11, and IGKJ3 genes are shown for reference. (C) Amino acid sequences of the CDR3 of the nearly identical Ig heavy and light chains expressed by the 10 unrelated CLL patients of subgroup CLL69C. Alignments of the amino acid sequences of the 51p1 encoded heavy chains and IGLV3-9 light chains are shown compared with CLL69C1. Dots indicate homology and dashes indicate no sequence at that position. Listed on the left is the designation for each CLL sample. The germline sequences of the IGHD3-3, IGHJ6, IGLV3-9, and IGLJ2 genes are shown for reference. (d) Amino acid sequences of the CDR3 of the nearly identical Ig heavy and light chains expressed by the 25 unrelated CLL patients of subgroup CLL69A. Alignments of the amino acid sequences of the 51p1 encoded heavy chains and IGKV3-20 light chains are shown compared with CLL69A1. Dots indicate homology and dashes indicate no sequence at that position. Listed on the left is the designation for each CLL sample. The germline sequences of the IGHD3-16, IGHJ3, IGKV3-20, and IGKJ4 genes are shown for reference. Underlined letters (X) designate amino acid differences between the germline IGKJ genes relative to IGKJ4.

Amino acid sequences of the CDR3 of the nearly identical Ig heavy and light chains. (A) Amino acid sequences of the CDR3 of the nearly identical Ig heavy and light chains expressed by the 19 unrelated CLL patients of subgroup CLL69B. Alignments of the amino acid sequences of the 51p1 encoded heavy chains and IGKV1-39 light chains are shown compared with CLL69B2. Dots indicate homology and dashes indicate no sequence at that position. Listed on the left is the designation for each CLL sample. The germline sequences of the IGHD2-2, IGHJ6, IGKV1-39 and IGKJ4 genes are shown for reference. Underlined letters (X) designate amino acid differences between the germline IGKJ genes relative to IGKJ4. (B) Amino acid sequences of the CDR3 of the nearly identical Ig heavy and light chains expressed by the 5 unrelated CLL patients of subgroup CLL69D. Alignments of the amino acid sequences of the 51p1 encoded heavy chains and IGKV3-11 light chains are shown compared with CLL69D1. Dots indicate homology and dashes indicate no sequence at that position. Listed on the left is the designation for each CLL sample. The germline sequences of the IGHD2-2, IGHJ6, IGKV3-11, and IGKJ3 genes are shown for reference. (C) Amino acid sequences of the CDR3 of the nearly identical Ig heavy and light chains expressed by the 10 unrelated CLL patients of subgroup CLL69C. Alignments of the amino acid sequences of the 51p1 encoded heavy chains and IGLV3-9 light chains are shown compared with CLL69C1. Dots indicate homology and dashes indicate no sequence at that position. Listed on the left is the designation for each CLL sample. The germline sequences of the IGHD3-3, IGHJ6, IGLV3-9, and IGLJ2 genes are shown for reference. (d) Amino acid sequences of the CDR3 of the nearly identical Ig heavy and light chains expressed by the 25 unrelated CLL patients of subgroup CLL69A. Alignments of the amino acid sequences of the 51p1 encoded heavy chains and IGKV3-20 light chains are shown compared with CLL69A1. Dots indicate homology and dashes indicate no sequence at that position. Listed on the left is the designation for each CLL sample. The germline sequences of the IGHD3-16, IGHJ3, IGKV3-20, and IGKJ4 genes are shown for reference. Underlined letters (X) designate amino acid differences between the germline IGKJ genes relative to IGKJ4.

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